Updated September 2015


Be an RNA engineer! Your design might even destroy a deadly disease

Subjects & skills
  • Science

  • Critical Thinking
Grades This grade range is based on learning appropriateness and doesn't take into account privacy. It's determined by Common Sense Education, not the product's publisher.
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High School biology teachers can use NOVA Labs: RNA to help kids see why RNA matters. Prior to using this resource, students should have a basic idea of the structure and function of DNA. Short videos are provided to give kids background knowledge about RNA and protein synthesis. After that, Nova Labs takes things a step further by showing students how we can capitalize on the ways that RNA molecules fight viruses to fight other diseases. Once they've got the background information, students can do puzzles that show how RNA folds, and they can design biomolecules online. What's more, these puzzles have a real purpose. If kids get good enough, the biomolecules they create might actually be used by scientists looking to turn off bad genes and fight diseases.

After playing, ask kids how new knowledge about RNA challenges the central dogma of molecular biology: DNA makes RNA and RNA makes protein. See if they can create a model that also accounts for the ways that RNA can influence DNA. While playing, you might notice that the game doesn’t follow the Watston and Crick base pair rules, and that Uracil bonds Guanine. This reflects a wobble that might be beyond the scope of many high school biology classes.  


  • Virus Wars -- Watch this short animated video to find out how cells fight viruses using RNA.
  • RNA VirtuaGame -- Be a molecule engineer and solve RNA folding puzzles.
  • The RNA Enigma -- Watch a video introduction to see why RNA matters.
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Teacher Reviews

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Featured review by
Donna M. , Classroom teacher
Classroom teacher
Vista Visions Academy
Vista, United States
Design RNA Molecules and Save a Life!
I really like the opportunity for interested students to be able to engage in real-world research. The lab itself presents accurate content in a fun way. The educator guide is well-organized with applicable NGSS standards aligned and additional NOVA resources linked to enable teachers to easily create a unit. Traditionally, I did not take a week or more to teach RNA, but the connections to actual research in this lab are invaluable. Another factor to keep in mind is that this site requires Flash so many ...
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